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This imbalance involves an intense and disabling vascular headache that often lasts for two hours to two days. Migraines are characterized by severe pain on one or both sides of the head. They generally involve a throbbing or a pounding sharp pain, and are often accompanied by visual disturbances and/or nausea and vomiting. Migraines are common, affecting 15-20 percent of men and 25-30 percent of women. In a common migraine, the pain of the headache develops slowly, sometimes mounting to a throbbing pain that is made worse by movement or noise.

Classical migraines are relatively rare. A slowly expanding area of blindness surrounded by a sparkling edge precedes these headaches; these symptoms involve up to one-half of the field of vision of each eye. The blindness may resolve after 20 minutes, which is often followed by a severe one-sided headache with nausea, vomiting, hypersensitivity to light and hypersensitivity to sound.

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